BCL2L2 and BIK

Number of citations of the paper that reports this interaction (PubMedID 15694340)
667

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		BCL2L2	BIK
Description		BCL2 like 2	BCL2 interacting killer
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding	Protein Binding
	Biological Process	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Complex Assembly Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196)	Prostate cancer ( 25939597 21743057) Prostate cancer (SNP x SNP interaction) ( 22219177)
Interacting Genes		17 interacting genes: BAD BAX BBC3 BCL2L11 BID BIK BMF BNIP3 FATE1 HRK KASH5 LMNA PPP1CA S100B TCF4 TEX11 TP53	13 interacting genes: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CREB3 CRKL FATE1 MCL1 NR2F2 S100A1 SOCS3 TANK
Entrez ID		599	638
HPRD ID		03569	04547
Ensembl ID		ENSG00000129473	ENSG00000100290
Uniprot IDs		Q92843	A0A024R4X6 Q13323
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	2IPE
Enriched GO Terms of Interacting Partners?
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