BCL2L2 and BBC3

Number of citations of the paper that reports this interaction (PubMedID 15694340)
667

Data Source:
HPRD (in vitro)

		BCL2L2	BBC3
Description		BCL2 like 2	BCL2 binding component 3
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex	Mitochondrion Lysosome
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding	Protein Binding ATPase Binding
	Biological Process	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Release Of Cytochrome C From Mitochondria Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Release Of Cytochrome C From Mitochondria Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release FOXO-mediated transcription of cell death genes
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196)	Monocyte count ( 27863252)
Interacting Genes		17 interacting genes: BAD BAX BBC3 BCL2L11 BID BIK BMF BNIP3 FATE1 HRK KASH5 LMNA PPP1CA S100B TCF4 TEX11 TP53	6 interacting genes: BAX BCL2 BCL2A1 BCL2L1 BCL2L2 MCL1
Entrez ID		599	27113
HPRD ID		03569	16165
Ensembl ID		ENSG00000129473	ENSG00000105327
Uniprot IDs		Q92843	Q96PG8 Q9BXH1
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	2M04 4BPI 4BPJ 4BPK 4HNJ 5UUL 6QFM 6QG8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?