BIK and NR2F2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		BIK	NR2F2
Description		BCL2 interacting killer	nuclear receptor subfamily 2 group F member 2
Image
GO Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Retinoic Acid Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Complex Assembly Positive Regulation Of Release Of Cytochrome C From Mitochondria	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Maternal Placenta Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Signal Transduction Skeletal Muscle Tissue Development Fertilization Anterior/posterior Pattern Specification Radial Pattern Formation Negative Regulation Of Endothelial Cell Migration Cell Differentiation Intracellular Receptor Signaling Pathway Forebrain Development Response To Estradiol Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Blood Vessel Morphogenesis Anatomical Structure Development Limb Development Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Prostate cancer ( 25939597 21743057) Prostate cancer (SNP x SNP interaction) ( 22219177)	Adventurousness ( 30643258) Birth weight ( 31043758) Cannabis use ( 27023175) Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia ( 29274321) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphangioleiomyomatosis (sporadic) ( 31000673) Metabolite levels ( 23823483) Motion sickness ( 25628336) Optic disc area ( 25631615) Optic disc size ( 31809533) Photic sneeze reflex ( 27182965) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Sex hormone-binding globulin levels ( 22829776) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659)
Interacting Genes		13 interacting genes: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CREB3 CRKL FATE1 MCL1 NR2F2 S100A1 SOCS3 TANK	18 interacting genes: BCL11A BCL11B BIK EP300 HDAC1 HIPK3 MYOD1 NCOR2 NR2F6 NR3C1 NSD1 PHB2 PIAS1 SETD7 SQSTM1 TENT5A TRIM24 TRIP4
Entrez ID		638	7026
HPRD ID		04547	00139
Ensembl ID		ENSG00000100290	ENSG00000185551
Uniprot IDs		A0A024R4X6 Q13323	F1D8R0 P24468
PDB IDs		2IPE	3CJW
Enriched GO Terms of Interacting Partners?
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