REST and HTT

Number of citations of the paper that reports this interaction (PubMedID 12881722)
279

Data Source:
HPRD (in vivo)

		REST	HTT
Description		RE1 silencing transcription factor	huntingtin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcriptional Repressor Complex	Cell Nucleus Nucleoplasm Cytoplasm Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Centriole Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Metal Ion Binding	P53 Binding Protein Binding Profilin Binding Kinase Binding Heat Shock Protein Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome Response To Hypoxia Hematopoietic Progenitor Cell Differentiation Response To Ischemia Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Aldosterone Biosynthetic Process Somatic Stem Cell Population Maintenance Cellular Response To Drug Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation By Host Of Viral Transcription Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Negative Regulation Of Neurogenesis Cardiac Muscle Cell Myoblast Differentiation Histone H4 Deacetylation Cellular Response To Electrical Stimulus Cellular Response To Glucocorticoid Stimulus Neuronal Stem Cell Population Maintenance Modification Of Synaptic Structure Positive Regulation Of Stem Cell Population Maintenance Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Amniotic Stem Cell Differentiation	Establishment Of Mitotic Spindle Orientation Retrograde Vesicle-mediated Transport, Golgi To ER Apoptotic Process Golgi Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Destabilization Vocal Learning Positive Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Cilium Assembly Vesicle Transport Along Microtubule Microtubule-based Transport Positive Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Lipophagy Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of Aggrephagy Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		HDACs deacetylate histones Regulation of PTEN gene transcription NGF-stimulated transcription	Regulation of MECP2 expression and activity
Drugs			Copper
Diseases			Huntington's disease (HD)
GWAS		Adventurousness ( 30643258) Age-related macular degeneration ( 21909106) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Height ( 25429064 31562340) Mean platelet volume ( 27863252) Migraine ( 27322543) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Platelet count ( 29403010) Response to bleomycin (chromatid breaks) ( 21106707) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation (ever regular vs never regular) ( 30679032)	Alcohol consumption ( 31358974) Estimated glomerular filtration rate ( 31152163) Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monobrow ( 27182965) Serum sulfate level ( 27412988) Tuberculosis ( 29036319) Type 2 diabetes ( 30297969) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		11 interacting genes: AURKA CDYL CEP135 GTF2B HTT MAPK1 PLK1 RCOR1 SIN3B SUB1 TBP	109 interacting genes: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CEP126 CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ELP1 ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 H2AP H3C10 HAP1 HEYL HIP1 HIP1R HOXC11 HOXC4 HSP90AA1 HSPA8 HYPK IFT20 IKBKB ING5 KAT2B MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUP58 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RHEB RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		5978	3064
HPRD ID		08990	00883
Ensembl ID		ENSG00000084093	ENSG00000197386
Uniprot IDs		Q13127	P42858
PDB IDs		2CZY 6DU2 6DU3	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED 4RAV 6EZ8 6N8C
Enriched GO Terms of Interacting Partners?
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