RAB4A and HACE1

Number of citations of the paper that reports this interaction (PubMedID 21988917)
31

Data Source:
BioGRID (pull down)

		RAB4A	HACE1
Description		RAB4A, member RAS oncogene family	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Endomembrane System Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane	Golgi Membrane Cytoplasm Endoplasmic Reticulum Nuclear Body Golgi Cisterna Membrane
	Molecular Function	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding	Ubiquitin-protein Transferase Activity Protein Binding Rab GTPase Binding Rac GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Aging ( 22773346) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448622 27182965) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		31 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830	9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3
Entrez ID		5867	57531
HPRD ID		01541	17086
Ensembl ID		ENSG00000168118	ENSG00000085382
Uniprot IDs		A0A024R3U9 A0A087WYT5 P20338	Q8IYU2
PDB IDs		1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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