RAB4A and GDI2

Number of citations of the paper that reports this interaction (PubMedID 10512627)
18

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		RAB4A	GDI2
Description		RAB4A, member RAS oncogene family	GDP dissociation inhibitor 2
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Cytosol Plasma Membrane Endomembrane System Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Secretory Granule Lumen Azurophil Granule Lumen Synapse Extracellular Exosome
	Molecular Function	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding	RNA Binding Rab GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Intracellular Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity	Signal Transduction Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Neutrophil Degranulation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling	Rho GTPase cycle Neutrophil degranulation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aging ( 22773346) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)	Blood protein levels ( 30072576) Osteosarcoma ( 23727862)
Interacting Genes		31 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 GDI2 GRIPAP1 HACE1 IDH3A KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830	8 interacting genes: GLRA2 HSPB1 RAB11A RAB2A RAB4A RAB5A RAB8A RAB9A
Entrez ID		5867	2665
HPRD ID		01541	02863
Ensembl ID		ENSG00000168118	ENSG00000057608
Uniprot IDs		A0A024R3U9 A0A087WYT5 P20338	P50395 Q6IAT1
PDB IDs		1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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