HACE1 and SNTG2

Number of citations of the paper that reports this interaction (PubMedID 27404360)
9

Data Source:
BioGRID (enzymatic study, pull down)

		HACE1	SNTG2
Description		HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	syntrophin gamma 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Nuclear Body Golgi Cisterna Membrane	Intracellular Cytoplasm Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Sarcolemma
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Rab GTPase Binding Rac GTPase Binding Ubiquitin Protein Ligase Activity	Actin Binding Structural Molecule Activity Protein Binding PDZ Domain Binding Neuroligin Family Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Golgi Organization Cell Cycle Protein Ubiquitination Rac Protein Signal Transduction Regulation Of Cell Migration Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Membrane Fusion Protein K48-linked Ubiquitination	Central Nervous System Development
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Feeling guilty ( 29500382) Height ( 18391951) Intraocular pressure ( 29617998) Major depressive disorder ( 27479909) Menarche (age at onset) ( 19448622 27182965) Multiple sclerosis ( 23412934) Neuroblastoma ( 22941191) Obsessive-compulsive disorder ( 22889921) Resistant hypertension ( 31545351) Schizophrenia ( 28991256) Sporadic neuroblastoma ( 28545128) Thyroid stimulating hormone levels ( 17903292) Type 2 diabetes ( 31049640) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in inactive individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Familial squamous cell lung carcinoma ( 29924316) Hypothyroidism ( 27182965) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		9 interacting genes: MTDH OPTN PAK1 PLXNA2 RAB4A RAC1 SNTG2 UBE2D2 UBE2L3	10 interacting genes: ADGRB1 BET1 DMD DTNA DTNB HACE1 MPP3 RPS6KA1 SCN5A VCPIP1
Entrez ID		57531	54221
HPRD ID		17086	16374
Ensembl ID		ENSG00000085382	ENSG00000172554
Uniprot IDs		Q8IYU2	Q9NY99
PDB IDs
Enriched GO Terms of Interacting Partners?
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