PVR and CD226

Number of citations of the paper that reports this interaction (PubMedID 12913096)
229

Data Source:
HPRD (in vitro)

		PVR	CD226
Description		PVR cell adhesion molecule	CD226 molecule
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Protein Homodimerization Activity Cell Adhesion Molecule Binding	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Susceptibility To Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Viral Entry Into Host Cell Regulation Of Immune Response Susceptibility To T Cell Mediated Cytotoxicity	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		Sphingosine Myristic acid
Diseases			Type I diabetes mellitus
GWAS		Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Mean platelet volume ( 27863252) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697 31194788 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 21829393 25751624 17554260)
Interacting Genes		25 interacting genes: AP1M2 CD226 CD96 DMPK DYNLT1 DYNLT3 GMEB2 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 NECTIN1 NECTIN2 NECTIN3 NOTCH2NLA PLA2G3 PLAT PSG11 PSG9 PSMD8 SLC22A4 SLC30A2 TIGIT VTN WNK1	4 interacting genes: FYN ITGB2 NECTIN2 PVR
Entrez ID		5817	10666
HPRD ID		01434	09252
Ensembl ID		ENSG00000073008	ENSG00000150637
Uniprot IDs		A0A0A0MSA9 A0A0C4DG49 A8K4I1 P15151	J3QR77 Q15762
PDB IDs		1DGI 1NN8 3EPC 3EPD 3EPF 3J8F 3J9F 3UDW 3URO 4FQP 6ARQ 6ISC 6O3O	6ISB 6O3O
Enriched GO Terms of Interacting Partners?
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