CD226 and ITGB2

Number of citations of the paper that reports this interaction (PubMedID 10591186)
57

Data Source:
HPRD (in vivo)

		CD226	ITGB2
Description		CD226 molecule	integrin subunit beta 2
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Extracellular Exosome Tertiary Granule Membrane Cytoplasmic Region Ficolin-1-rich Granule Membrane Extracellular Vesicle
	Molecular Function	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Regulation Of Cell Shape Cell Migration Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Neuron Death Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs			Simvastatin
Diseases		Type I diabetes mellitus	Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 23128233) Mean platelet volume ( 22139419 19820697 31194788 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Rheumatoid arthritis ( 30423114 24390342) Type 1 diabetes ( 21829393 25751624 17554260)	Heel bone mineral density ( 28869591)
Interacting Genes		4 interacting genes: FYN ITGB2 NECTIN2 PVR	45 interacting genes: C3 CD14 CD226 CD82 CHPF COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SHARPIN SYK TLN1 VNN2
Entrez ID		10666	3689
HPRD ID		09252	02506
Ensembl ID		ENSG00000150637	ENSG00000160255
Uniprot IDs		J3QR77 Q15762	A0A494C0X7 B4E0R1 P05107
PDB IDs		6ISB 6O3O	1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ
Enriched GO Terms of Interacting Partners?
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