PTBP2 and KHSRP

Number of citations of the paper that reports this interaction (PubMedID 11003644)
138

Data Source:
BioGRID (pull down)

		PTBP2	KHSRP
Description		polypyrimidine tract binding protein 2	KH-type splicing regulatory protein
Image
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Growth Cone Neuronal Cell Body	Exosome (RNase Complex) Nucleoplasm Cytosol Cytoplasmic Stress Granule Membrane
	Molecular Function	RNA Binding MRNA Binding	DNA Binding RNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	MRNA Splice Site Selection Regulation Of Translation Spinal Cord Development Cerebellum Development Negative Regulation Of RNA Splicing Regulation Of RNA Splicing Regulation Of Neural Precursor Cell Proliferation	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing MRNA Catabolic Process RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus Regulation Of MiRNA Metabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs			Resveratrol Artenimol
Diseases
GWAS		Anorexia nervosa ( 31308545) Autism spectrum disorder ( 30804558) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically inactive individuals ( 28448500) Chronotype ( 30696823) Headache ( 29397368) Hip circumference ( 25673412) Number of sexual partners ( 30643258) Reaction time ( 29844566) Regular attendance at a pub or social club ( 29970889) Schizophrenia ( 19571811 22688191) Smoking status (ever vs never smokers) ( 30643258) Trunk fat mass adjusted for trunk lean mass ( 30944420) Waist circumference ( 25673412)
Interacting Genes		20 interacting genes: CALCOCO2 EIF5A2 ELAVL1 GBP1 GOLGA2 HNRNPAB HNRNPC HNRNPD KHDRBS1 KHDRBS3 KHSRP MATR3 PCBP3 PKN2 PUF60 QKI RBM10 RBM4 SNRPA TOM1	15 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GCC1 GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I
Entrez ID		58155	8570
HPRD ID		12233	10350
Ensembl ID		ENSG00000117569	ENSG00000088247
Uniprot IDs		B4DSS8 B4DSU5 Q9UKA9	Q92945
PDB IDs		2CQ1 2MJU 4CQ1	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?
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