PTN and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PTN	TP53BP2
Description		pleiotrophin	tumor protein p53 binding protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Plasma Membrane Cell Surface Neuromuscular Junction Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Postsynapse	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Phosphatase Inhibitor Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Protein Kinase Binding Chondroitin Sulfate Proteoglycan Binding Chondroitin Sulfate Binding Vascular Endothelial Growth Factor Binding Syndecan Binding Heparan Sulfate Binding	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Liver Development Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Integrin-mediated Signaling Pathway Nervous System Development Negative Regulation Of Neuroblast Proliferation Heart Development Learning Memory Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Response To Activity Negative Regulation Of Angiogenesis Spinal Cord Development Cerebellum Development Thalamus Development Bone Mineralization Lung Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Dendrite Regeneration Regulation Of Myelination Response To Estradiol Negative Regulation Of Phosphoprotein Phosphatase Activity Response To Progesterone Cellular Response To UV Cellular Response To Platelet-derived Growth Factor Stimulus Tissue Regeneration Positive Regulation Of Apoptotic Process Receptor Clustering Ossification Involved In Bone Remodeling Estrous Cycle Endothelial Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Membrane Potential Decidualization Regulation Of Synaptic Plasticity Oogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Retinal Rod Cell Differentiation Negative Regulation Of Glial Cell Proliferation Long-term Synaptic Potentiation Cellular Response To Vitamin D Cellular Response To Hypoxia Negative Regulation Of Mesenchymal Cell Proliferation Dendrite Arborization Positive Regulation Of Dendrite Development Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Hemopoiesis Response To Kainic Acid Rod Bipolar Cell Differentiation Response To Ciliary Neurotrophic Factor Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Neuromuscular Junction Development Response To Nerve Growth Factor Regulation Of Stem Cell Population Maintenance Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Stem Cell Differentiation	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Aluminium levels ( 26025379) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurociticism ( 29500382) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Schizophrenia ( 25056061 29483656)	Triptolide cytotoxicity ( 26121980)
Interacting Genes		97 interacting genes: ACTB ALK APOBEC3G ARIH2 ARL15 ATP5F1C ATRX BAG6 BARD1 BCCIP BCL2L1 BLOC1S1 BMI1 BTBD2 C11orf58 C7orf25 CAAP1 CACNB4 CAPZB CDH10 CDK5RAP2 CGA CHD3 COX6C CRCT1 CRELD1 CSTA CYP2E1 DNAJB11 DUSP12 EIF3F EVA1A FEZ1 FTL GADD45A GADD45G GIPC2 GLYAT GPD1 GPRASP2 GSDME GSK3B GSTP1 GTF2F1 HGH1 HSPBAP1 ITSN2 KPNB1 LAMA4 LUC7L2 MAD2L1BP MKKS MLLT3 MRPL44 MYCBP NAP1L5 NCAN NEK6 NUDT21 P4HB PFDN1 PIAS4 PLXNB2 PMF1 PPP2CA PSMB10 PSMD11 PSMD2 PTPRS PTPRZ1 RACK1 RBM23 RIT1 RPLP1 SAT1 SDC1 SDC3 SGSM2 SGTA SLC25A36 SNCAIP SPIN1 SSR1 STC2 SUPT7L TAC3 TAF1D TBRG4 TOMM20 TP53BP2 TSC22D1 TXNDC9 UBQLN1 UBQLN4 UTP3 WASHC3 WFDC2	64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26
Entrez ID		5764	7159
HPRD ID		01199	11803
Ensembl ID		ENSG00000105894	ENSG00000143514
Uniprot IDs		A0A024R778 P21246	Q13625
PDB IDs		2N6F	1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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