SH3RF1 and MAP3K9

Number of citations of the paper that reports this interaction (PubMedID 14504284)
24

Data Source:
HPRD (in vitro)

		SH3RF1	MAP3K9
Description		SH3 domain containing ring finger 1	mitogen-activated protein kinase kinase kinase 9
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cellular_component
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Neuron Migration Apoptotic Process Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Apoptotic Process Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Anthropometric traits (multi-trait analysis) ( 30166351) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309)
Interacting Genes		19 interacting genes: ADAM15 AKT1 AKT2 HERPUD1 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N	2 interacting genes: SH3RF1 SMURF1
Entrez ID		57630	4293
HPRD ID		15335	15965
Ensembl ID		ENSG00000154447	ENSG00000006432
Uniprot IDs		Q7Z6J0	A0A087WW79 B4DZC4 G3V347 J3KPI6 P80192 Q8NEB1
PDB IDs			3DTC 4UY9
Enriched GO Terms of Interacting Partners?
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