SH3RF1 and MAP4K3

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		SH3RF1	MAP4K3
Description		SH3 domain containing ring finger 1	mitogen-activated protein kinase kinase kinase kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity
	Biological Process	Neuron Migration Apoptotic Process Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation JNK Cascade Regulation Of Mitotic Cell Cycle Response To UV Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Response To Tumor Necrosis Factor Intracellular Signal Transduction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Bone mineral density ( 31790847)
Interacting Genes		19 interacting genes: ADAM15 AKT1 AKT2 HERPUD1 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N	7 interacting genes: BIN1 COPS5 GRB2 ITSN2 SH3GL2 SH3RF1 SORBS1
Entrez ID		57630	8491
HPRD ID		15335	05373
Ensembl ID		ENSG00000154447	ENSG00000011566
Uniprot IDs		Q7Z6J0	A8K602 B3KMM5 Q8IVH8
PDB IDs			5J5T
Enriched GO Terms of Interacting Partners?
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