TSHZ3 and CEP63

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TSHZ3	CEP63
Description		teashirt zinc finger homeobox 3	centrosomal protein 63
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Plasma Membrane Growth Cone	Spindle Pole Centrosome Centriole Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Chronotype ( 30696823) Cognitive performance ( 19734545) Corneal astigmatism ( 30306274) Diastolic blood pressure ( 27841878) FEV1 ( 30804560) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Lung function (FEV1/FVC) ( 30061609 30804560) Peak expiratory flow ( 30804560) Photic sneeze reflex ( 27182965) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Post bronchodilator FEV1 in COPD ( 26634245) Systemising ( 31508503) Systolic blood pressure ( 27841878) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Height ( 18391952) Late-onset Alzheimer's disease ( 27770636) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		16 interacting genes: APBB1 CEP63 CEP70 CTBP1 CTBP2 KASH5 KRT40 MAD1L1 MTUS2 SPAG5 TAX1BP1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54	42 interacting genes: ALOX5 ARFIP2 ARNT2 CAMKK2 CCNI CDK1 CEP57L1 DISC1 DST DTNB DZIP3 EXOC4 EZH2 FAM161A FBF1 GSE1 HAUS1 HGS INTS6L KXD1 MACF1 MBIP NCOR2 NDEL1 NXT2 PCNX4 POLR3C PPP1R13B PPP4R1 SMARCE1 SMC3 SNRNP70 SPTAN1 SPTBN1 SSX3 SYNE1 SYT17 TBC1D15 TSHZ3 TXLNA USHBP1 ZCCHC10
Entrez ID		57616	80254
HPRD ID		18351	07826
Ensembl ID		ENSG00000121297	ENSG00000182923
Uniprot IDs		Q63HK5	Q96MT8
PDB IDs		2DMI	6CSU 6CSV
Enriched GO Terms of Interacting Partners?
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