GATAD2B and MBD3

Number of citations of the paper that reports this interaction (PubMedID 12183469)
34

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GATAD2B	MBD3
Description		GATA zinc finger domain containing 2B	methyl-CpG binding domain protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm NuRD Complex Nuclear Speck Protein-containing Complex	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Protein Binding Zinc Ion Binding Nucleosomal DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II ATP-dependent Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Chronotype ( 30696823) Empathy quotient ( 29527006) General cognitive ability ( 29844566) Height ( 31562340) Lentiform nucleus volume ( 22903471) Number of children ever born ( 27798627)
Interacting Genes		20 interacting genes: CALCOCO2 CEP70 GOLGA2 H2AC20 H2BC21 H3C1 H4C1 KAT2B MBD2 MBD3 MTNR1A PRKAB2 RBPMS RPGRIP1 SMAD2 SUMO2 TEX11 TRAF1 TRIM27 USHBP1	29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277
Entrez ID		57459	53615
HPRD ID		15094	04653
Ensembl ID		ENSG00000143614	ENSG00000071655
Uniprot IDs		Q8WXI9	O95983
PDB IDs			2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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