RPGRIP1 and AEN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RPGRIP1	AEN
Description		RPGR interacting protein 1	apoptosis enhancing nuclease
Image			No pdb structure
GO Annotations	Cellular Component	Axoneme Photoreceptor Connecting Cilium	Nucleus Nucleoplasm Nucleolus Nuclear Membrane
	Molecular Function	Protein Binding	Nucleic Acid Binding Exonuclease Activity Protein Binding
	Biological Process	Visual Perception Eye Photoreceptor Cell Development Response To Stimulus Retina Development In Camera-type Eye Neural Precursor Cell Proliferation	DNA Catabolic Process, Exonucleolytic RNA Catabolic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Viral Genome Replication Defense Response To Virus
Pathways
Drugs
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Height ( 31562340) Superior temporal sulcus banks volume ( 31530798)	Dupuytren's disease ( 28886342) Night sleep phenotypes ( 27126917)
Interacting Genes		26 interacting genes: AEN BRCA1 CBX8 CCDC146 CHCHD3 CSPP1 DPPA4 FAM74A4 FEM1C GATAD2B HEYL IQCE MAGEB2 NPHP4 PTF1A RNF6 RPGR RPP25L SCNM1 TBC1D7 TFPT TRIB3 ZNF337 ZNF417 ZNF564 ZNF688	34 interacting genes: CRTC3 EMD EXOSC8 GNPTAB HOMEZ IKZF1 KHDRBS2 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 LZTS2 MBNL1 MID2 MTUS2 NKX3-1 PDE4DIP PHC2 RALYL RBMY1A1 RBMY1F RPGRIP1 SPOP SSX2IP TLE5 TRIM27 TRIM41 ZBTB43 ZBTB8A ZFP64 ZNF317 ZNF473
Entrez ID		57096	64782
HPRD ID		05673	08573
Ensembl ID		ENSG00000092200	ENSG00000181026
Uniprot IDs		Q96KN7	Q8WTP8
PDB IDs		4QAM
Enriched GO Terms of Interacting Partners?
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