RAD18 and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 24958773)
15

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RAD18	SIVA1
Description		RAD18 E3 ubiquitin protein ligase	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Nuclear Body Site Of Double-strand Break Nuclear Inclusion Body Rad6-Rad18 Complex	Nucleoplasm Cytoplasm
	Molecular Function	Y-form DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Single-stranded DNA-dependent ATP-dependent DNA Helicase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding
	Biological Process	DNA Repair Postreplication Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Protein Ubiquitination DNA Damage Response, Detection Of DNA Damage Protein Autoubiquitination Positive Regulation Of Chromosome Segregation Negative Regulation Of Cell Death	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway
Pathways		Recognition of DNA damage by PCNA-containing replication complex E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Zinc
Diseases
GWAS		Chronotype ( 30696823) Clopidogrel active metabolite levels ( 28207573) Metabolite levels ( 23823483) Morning person ( 30696823) Sleep duration ( 30531941) Transverse temporal cortex volume ( 31530798)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401)
Interacting Genes		25 interacting genes: DZIP3 MAGEA4 MAP3K1 MAPK8 MLKL NBN PCGF6 PCNA POLK RAD51 RFC2 SHPRH SIVA1 TAX1BP1 TP53BP1 TRIM23 TRIM8 TSG101 UBC UBE2A UBE2B UBE2D2 UBE2I USP2 USP7	20 interacting genes: ABL2 APP BAG5 BCL2L1 BEX3 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L PCNA POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TNFRSF4 UBE2D1
Entrez ID		56852	10572
HPRD ID		09242	16124
Ensembl ID		ENSG00000070950	ENSG00000184990
Uniprot IDs		Q9NS91	O15304
PDB IDs		2MRE 2MRF 2Y43 2YBF 5VF0
Enriched GO Terms of Interacting Partners?
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