SIVA1 and ABL2

Number of citations of the paper that reports this interaction (PubMedID 11278261)
21

Data Source:
HPRD (in vitro)

		SIVA1	ABL2
Description		SIVA1 apoptosis inducing factor	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Cell Cytosol Actin Cytoskeleton
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Metal Ion Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Viral Entry Into Host Cell Extrinsic Apoptotic Signaling Pathway	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Regulation Of Apoptotic Process Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways			Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling
Drugs		Zinc	ATP Dasatinib XL228 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401)	IgE grass sensitization ( 22036096)
Interacting Genes		20 interacting genes: ABL2 APP BAG5 BCL2L1 BEX3 CD27 CD4 CDKN2A MEFV NEDD4 NEDD4L PCNA POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TNFRSF4 UBE2D1	29 interacting genes: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 MDM2 NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10
Entrez ID		10572	27
HPRD ID		16124	01259
Ensembl ID		ENSG00000184990	ENSG00000143322
Uniprot IDs		O15304	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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