TWNK and SMAD9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
85

Data Source:
HPRD (two hybrid)

		TWNK	SMAD9
Description		twinkle mtDNA helicase	SMAD family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	Nuclear Chromatin Intracellular Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol SMAD Protein Complex
	Molecular Function	Protease Binding DNA Helicase Activity Single-stranded DNA Binding ATP Binding Identical Protein Binding 5'-3' DNA Helicase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Metal Ion Binding
	Biological Process	Mitochondrial DNA Replication DNA Unwinding Involved In DNA Replication Mitochondrial Transcription Mitochondrion Organization Protein Hexamerization Cellular Response To Glucose Stimulus	Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Transcriptional activation of mitochondrial biogenesis	Signaling by BMP
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS			Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549 28869591) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Spontaneous preterm birth (preterm birth) ( 25599974) Total body bone mineral density ( 29304378)
Interacting Genes		2 interacting genes: AKTIP SMAD9	117 interacting genes: ABTB1 ACTB ACVR1 AFF1 AP2A1 ARHGAP9 ARID1B ARNT ASB2 ASH2L BAZ1A BTG2 CAMSAP1 CEP135 CHPF CLPB CPXM2 CSH1 CSH2 CTR9 CXXC5 CYP11A1 DIAPH3 DKK1 DNAJA3 DNAJC7 DST DSTN E4F1 EIF3C EIF3E EIF3F ERVV-1 EVC2 EXPH5 FLI1 FN1 FTL GRN HEY1 HEYL HUWE1 KDM1A KDM6A KMT2D LEMD3 LMO4 LNPEP LRP5 MACO1 MAN1A2 MAN1C1 MAN2B1 MBD1 MCM3AP METAP1 MGAT1 MTMR10 MTMR11 NAGK OTUB1 PABPC4 PAPPA PELP1 PHKA2 PIR PKP2 PLEC PNPLA2 PPARD PPP2R5E PRMT6 PSAP PSMD8 QARS1 RANBP9 RFX1 RMND5A RNF123 RRBP1 RUBCN SECISBP2 SF3B1 SIL1 SMAD2 SMAD3 SMAD4 SMG1 SNRNP70 SPTBN1 STAG1 SVEP1 TBCD TERF1 TINAGL1 TOB1 TRIM29 TRIP12 TTC37 TWNK UBA6 UBE3A UBQLN1 UBQLN4 UNC45A VCPIP1 VPS8 XAB2 YWHAQ ZEB2 ZNF484 ZNF557 ZNF587 ZNF587B ZNF592 ZNF83 ZSCAN4
Entrez ID		56652	4093
HPRD ID		05830	04484
Ensembl ID		ENSG00000107815	ENSG00000120693
Uniprot IDs		A0A2R8Y4V4 A0A2R8Y746 E5KSY5 Q96RR1 Q9H6V3	A0A024RDR3 O15198
PDB IDs			6FZT
Enriched GO Terms of Interacting Partners?
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