ERO1B and PARVA

		ERO1B	PARVA
Description		endoplasmic reticulum oxidoreductase 1 beta	parvin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Unfolded Protein Binding	Actin Binding Protein Binding Cadherin Binding
	Biological Process	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Insulin Processing Extracellular Matrix Organization Protein Folding In Endoplasmic Reticulum Glucose Homeostasis Cell Redox Homeostasis Oxidation-reduction Process	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis
Pathways		Insulin processing	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases
GWAS			Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)
Interacting Genes		10 interacting genes: ACTL6A BRCA1 CNRIP1 ERP44 GNG4 HMGCS2 P4HB PARVA PYGM TARBP1	15 interacting genes: ACTA1 APP ERO1B FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1
Entrez ID		56605	55742
HPRD ID		13279	16283
Ensembl ID		ENSG00000086619	ENSG00000197702
Uniprot IDs		Q86YB8	Q9NVD7
PDB IDs			2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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