MAP2K3 and MAP3K2

Number of citations of the paper that reports this interaction (PubMedID 9162092)
23

Data Source:
BioGRID (enzymatic study)

		MAP2K3	MAP3K2
Description		mitogen-activated protein kinase kinase 3	mitogen-activated protein kinase kinase kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Activation Of MAPK Activity Inflammatory Response Signal Transduction Regulation Of Mitotic Cell Cycle Peptidyl-tyrosine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus P38MAPK Cascade Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus
Pathways		Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation
Drugs			Bosutinib
Diseases
GWAS		Body mass index ( 26426971 28892062)	Protein C levels ( 28082259)
Interacting Genes		55 interacting genes: AKT1 ALDOC APP ARAF ARRB1 AURKA BECN1 BRAF CBLC CCND2 CD44 CDC42 CDK4 CDK6 CDKN2B CDKN2C DCTN1 DYRK1B ELK1 ERBB2 FZR1 GLIS2 HIF1A KAT2A KDELR2 LATS2 LRRK2 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK12 MAPK14 MAPK3 MAPK8IP2 MET NF1 NF2 NFIC PLCB2 PTEN RAF1 RASSF1 RPL13 SMAD1 SMAD7 STK11 TAOK1 TAOK2 TEAD2 TERT TINF2 TP53	25 interacting genes: BIRC2 CTNNB1 IKBKG MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAPK8 NEDD4 NEDD4L NFKBIA NGLY1 PIBF1 PKN2 SH2D2A SMURF1 STAMBP STUB1 USP2 WNK1 XIAP YWHAE YWHAG YWHAZ
Entrez ID		5606	10746
HPRD ID		03816	10068
Ensembl ID		ENSG00000034152	ENSG00000169967
Uniprot IDs		P46734 Q6FI23	A0A024RAH0 Q9Y2U5
PDB IDs			2CU1 2NPT 5EX0 5HQ8
Enriched GO Terms of Interacting Partners?
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