MAPK9 and NCSTN

Number of citations of the paper that reports this interaction (PubMedID 18667537)
15

Data Source:
BioGRID (enzymatic study)

		MAPK9	NCSTN
Description		mitogen-activated protein kinase 9	nicastrin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Mitochondrion Lysosomal Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Synaptic Vesicle Endosome Membrane Membrane Integral Component Of Membrane Azurophil Granule Membrane Sarcolemma Melanosome Extracellular Exosome Gamma-secretase Complex Integral Component Of Presynaptic Membrane
	Molecular Function	JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding	Endopeptidase Activity Protein Binding
	Biological Process	Protein Phosphorylation JNK Cascade JUN Phosphorylation Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Myeloid Cell Homeostasis Proteolysis Membrane Protein Ectodomain Proteolysis Dopamine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Notch Receptor Processing Learning Or Memory Protein Processing Cerebellum Development Central Nervous System Myelination Adult Behavior Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent T Cell Proliferation Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Neutrophil Degranulation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Epithelial Cell Proliferation Neuron Apoptotic Process Cellular Response To Calcium Ion Regulation Of Long-term Synaptic Potentiation Short-term Synaptic Potentiation
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	Nuclear signaling by ERBB4 Degradation of the extracellular matrix Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells Neutrophil degranulation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs		N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Diseases			Acne inversa; Hidradenitis supprativa
GWAS		Blood protein levels ( 30072576)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		77 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 FBXO7 GRB2 H3-3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND L3MBTL3 LMAN2 LNX1 LNX2 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MEOX1 NCF1 NCSTN NFATC3 NFATC4 PRKD1 PSEN1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25	11 interacting genes: ABL1 APH1A APH1B APP BACE1 MAPK9 PSEN1 PSEN2 PSENEN SPP1 TMED10
Entrez ID		5601	23385
HPRD ID		04206	05584
Ensembl ID		ENSG00000050748	ENSG00000162736
Uniprot IDs		D7R525 D7R526 P45984	B4DR82 Q92542
PDB IDs		3E7O 3NPC	2N7Q 2N7R 4UIS 5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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