MAPK9 and DUSP4

Number of citations of the paper that reports this interaction (PubMedID 8626452)
107

Data Source:
BioGRID (imaging technique, affinity chromatography technology)
HPRD (in vivo)

		MAPK9	DUSP4
Description		mitogen-activated protein kinase 9	dual specificity phosphatase 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Serine/threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation JNK Cascade JUN Phosphorylation Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Inactivation Of MAPK Activity Endoderm Formation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway
Drugs		N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Diseases
GWAS		Blood protein levels ( 30072576)	Gestational age at birth (maternal effect) ( 28598419) Postoperative complication after cardiac surgery ( 30678657) Response to statin therapy ( 20339536) Spontaneous preterm birth (maternal effect) ( 28598419)
Interacting Genes		77 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 FBXO7 GRB2 H3-3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND L3MBTL3 LMAN2 LNX1 LNX2 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MEOX1 NCF1 NCSTN NFATC3 NFATC4 PRKD1 PSEN1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25	9 interacting genes: APP CRMP1 GRIN1 GRIN2D MAPK1 MAPK14 MAPK3 MAPK8 MAPK9
Entrez ID		5601	1846
HPRD ID		04206	04123
Ensembl ID		ENSG00000050748	ENSG00000120875
Uniprot IDs		D7R525 D7R526 P45984	Q13115
PDB IDs		3E7O 3NPC	3EZZ
Enriched GO Terms of Interacting Partners?
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