MAPK11 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 20110267)
20

Data Source:
BioGRID (enzymatic study)

		MAPK11	NOXA1
Description		mitogen-activated protein kinase 11	NADPH oxidase activator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytosol NADPH Oxidase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Rac GTPase Binding
	Biological Process	Activation Of MAPK Activity Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Interleukin-12 Secretion	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Positive Regulation Of Catalytic Activity Regulation Of Respiratory Burst
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation	RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping
Drugs		KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181)	Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	14 interacting genes: CACNA1A EP300 FAT1 MAPK1 MAPK11 NCF1 NOX1 NOXO1 PRKACA PRKCA PRKCG RAC1 RAC2 RIMBP3
Entrez ID		5600	10811
HPRD ID		04208	17644
Ensembl ID		ENSG00000185386	ENSG00000188747
Uniprot IDs		Q15759	Q86UR1
PDB IDs		3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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