MAPK11 and CPNE6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MAPK11	CPNE6
Description		mitogen-activated protein kinase 11	copine 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Endosome Plasma Membrane Membrane Axon Dendrite Perikaryon Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Activation Of MAPK Activity Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Interleukin-12 Secretion	Lipid Metabolic Process Chemical Synaptic Transmission Nervous System Development Vesicle-mediated Transport Glycerophospholipid Biosynthetic Process Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation	Glycerophospholipid biosynthesis
Drugs		KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	13 interacting genes: AK5 ANXA7 CDKN1A GRB7 LAMTOR3 MAPK11 MEOX2 NOTCH3 OS9 PIN1 SMN1 TK1 TTR
Entrez ID		5600	9362
HPRD ID		04208	05748
Ensembl ID		ENSG00000185386	ENSG00000100884
Uniprot IDs		Q15759	B3KWK1 O95741
PDB IDs		3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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