BRK1 and CYFIP2

Number of citations of the paper that reports this interaction (PubMedID 8605018)
23

Data Source:
HPRD (in vitro, in vivo)

		BRK1	CYFIP2
Description		BRICK1 subunit of SCAR/WAVE actin nucleating complex	cytoplasmic FMR1 interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome	Nucleus Cytoplasm Cytosol Membrane Cell Junction SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Rac GTPase Binding	RNA 7-methylguanosine Cap Binding Protein Binding
	Biological Process	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein Complex Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cell Morphogenesis Apoptotic Process Axon Guidance Cell Projection Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Proteolysis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Dendrite Extension Cell-cell Adhesion
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810)	Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		7 interacting genes: BRAP CYFIP2 NCK1 NCKAP1 PFDN1 PIK3R3 WASF1	22 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP F2RL1 FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A
Entrez ID		55845	26999
HPRD ID		12818	07556
Ensembl ID		ENSG00000254999	ENSG00000055163
Uniprot IDs		Q8WUW1	B7Z8N7 E7EVJ5 Q96F07
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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