CYFIP2 and BRK1

Number of citations of the paper that reports this interaction (PubMedID 8605018)
23

Data Source:
HPRD (in vitro, in vivo)

		CYFIP2	BRK1
Description		cytoplasmic FMR1 interacting protein 2	BRICK1 subunit of SCAR/WAVE actin nucleating complex
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane Cell Junction SCAR Complex Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome
	Molecular Function	RNA 7-methylguanosine Cap Binding Protein Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Rac GTPase Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Axon Guidance Cell Projection Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Proteolysis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Dendrite Extension Cell-cell Adhesion	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein Complex Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Lung function (FEV1/FVC) ( 28166213 30804560) Peak expiratory flow ( 30804560)	Arterial stiffness index ( 31235810)
Interacting Genes		22 interacting genes: ABI1 ABI3 APBB1 BIRC3 BRK1 DNMBP F2RL1 FMR1 FXR1 FXR2 GAS7 MTDH NCK1 NCKAP1 PLG PRPF40A SMAD4 TCERG1 WASF1 WASF2 YWHAG ZC3H12A	7 interacting genes: BRAP CYFIP2 NCK1 NCKAP1 PFDN1 PIK3R3 WASF1
Entrez ID		26999	55845
HPRD ID		07556	12818
Ensembl ID		ENSG00000055163	ENSG00000254999
Uniprot IDs		B7Z8N7 E7EVJ5 Q96F07	Q8WUW1
PDB IDs			3P8C 4N78
Enriched GO Terms of Interacting Partners?
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