PRKAR2B and ABCB4

		PRKAR2B	ABCB4
Description		protein kinase cAMP-dependent type II regulatory subunit beta	ATP binding cassette subfamily B member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Neuronal Cell Body Dendritic Spine Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Phosphatidylcholine-translocating ATPase Activity Ceramide-translocating ATPase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Renal Water Homeostasis Fatty Acid Metabolic Process Blood Coagulation Learning Regulation Of G2/M Transition Of Mitotic Cell Cycle CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Cellular Response To Glucagon Stimulus Response To Clozapine Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of CAMP-dependent Protein Kinase Activity	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1
Drugs		Cyclic Adenosine Monophosphate
Diseases			Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266)	Alanine transaminase levels ( 29403010) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)
Interacting Genes		24 interacting genes: ABCB4 AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 CBR1 CFAP91 GNAI3 KIF5B LAMB1 LASP1 LRCH4 MT1H NBEA PAK1IP1 PRKACA RAP2B RPL30 TAF12 TFR2	4 interacting genes: HAX1 PIGY PRKAR2B TESK1
Entrez ID		5577	5244
HPRD ID		01486	01371
Ensembl ID		ENSG00000005249	ENSG00000005471
Uniprot IDs		A0A024R712 B3KY43 P31323	P21439
PDB IDs
Enriched GO Terms of Interacting Partners?
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