ABCB4

Description		ATP binding cassette subfamily B member 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Integral Component Of Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Raft Intercellular Canaliculus Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Phospholipid Transporter Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Phosphatidylcholine-translocating ATPase Activity Ceramide-translocating ATPase Activity
	Biological Process	Lipid Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cholesterol Transport Bile Acid Secretion Phospholipid Translocation Transmembrane Transport Lipid Homeostasis Positive Regulation Of Phospholipid Translocation Ceramide Translocation Response To Fenofibrate Cellular Response To Bile Acid Positive Regulation Of Phospholipid Transport
Pathways		PPARA activates gene expression ABC-family proteins mediated transport Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1
Drugs
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine transaminase levels ( 29403010) Epithelial ovarian cancer ( 25134534) Gallbladder cancer ( 28274756) Gallstone disease ( 30504769) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: HAX1 PIGY PRKAR2B TESK1
Entrez ID		5244
HPRD ID		01371
Ensembl ID		ENSG00000005471
Uniprot IDs		P21439
PDB IDs
Enriched GO Terms of Interacting Partners?
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