CDK5RAP2 and ZPR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDK5RAP2	ZPR1
Description		CDK5 regulatory subunit associated protein 2	ZPR1 zinc finger
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Cell Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Nucleus Nucleoplasm Nucleolus Cytoplasm Cajal Body Axon Growth Cone Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Gemini Of Coiled Bodies
	Molecular Function	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Transcription Regulatory Region DNA Binding	Protein Binding Zinc Ion Binding Receptor Tyrosine Kinase Binding Translation Initiation Factor Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking	Microtubule Cytoskeleton Organization Inner Cell Mass Cell Proliferation Trophectodermal Cell Proliferation MRNA Processing Signal Transduction Cell Proliferation RNA Splicing Positive Regulation Of Gene Expression Spinal Cord Development Cajal Body Organization Regulation Of Myelination Positive Regulation Of RNA Splicing DNA Endoreduplication Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Growth Axon Development Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Apoptotic Process Involved In Development Pre-mRNA Catabolic Process Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Coronary artery disease ( 29263402 29212778) Delirium ( 29631748) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 30382898 31589552) Postprandial triglyceride response to high fat diet meal ( 26256467) Total cholesterol levels ( 29615537) Triglyceride levels ( 29615537)
Interacting Genes		26 interacting genes: ABCA2 CDK5 CDK5R1 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 MRRF NEFL PCBD1 PHF19 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	7 interacting genes: AP2A2 CDK5RAP2 EEF1A1 EGFR MPP3 SNUPN SUMO4
Entrez ID		55755	8882
HPRD ID		09740	04877
Ensembl ID		ENSG00000136861	ENSG00000109917
Uniprot IDs		A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8	O75312
PDB IDs
Enriched GO Terms of Interacting Partners?
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