CDK5RAP2 and PHF19

		CDK5RAP2	PHF19
Description		CDK5 regulatory subunit associated protein 2	PHD finger protein 19
Image		No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Spindle Pole Cell Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Gamma-tubulin Ring Complex Cell Junction Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Exosome Mitotic Spindle Pole	Nucleus Nucleoplasm ESC/E(Z) Complex
	Molecular Function	Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Gamma-tubulin Binding Transcription Regulatory Region DNA Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Chromosome Segregation Centrosome Cycle Centriole Replication Brain Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Neurogenesis Microtubule Organizing Center Organization Positive Regulation Of Microtubule Polymerization Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Ciliary Basal Body-plasma Membrane Docking	Chromatin Organization Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K27 Methylation
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	PRC2 methylates histones and DNA
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Asthma ( 27611488) Height ( 28552196) Photic sneeze reflex ( 27182965) Response to statin therapy ( 20339536) Rheumatoid arthritis ( 24782177)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758 27680694) Corneal astigmatism ( 29422769) High density lipoprotein cholesterol levels ( 29403010) Prostate-specific antigen levels ( 28139693) Pulse pressure ( 28135244 27618448)
Interacting Genes		26 interacting genes: ABCA2 CDK5 CDK5R1 CRMP1 EEF1G ERG28 FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 MRRF NEFL PCBD1 PHF19 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1	5 interacting genes: CDK5RAP2 H3C1 KDM1A SUV39H1 SUV39H2
Entrez ID		55755	26147
HPRD ID		09740	17846
Ensembl ID		ENSG00000136861	ENSG00000119403
Uniprot IDs		A0A0A0MRG9 B3KVI2 B9EG74 Q7Z3M0 Q96SN8	A0A087X169 B7Z887 B7Z8H3 F5H8K3 Q5T6S3
PDB IDs			2E5Q 4BD3
Enriched GO Terms of Interacting Partners?
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