ASAP3 and ARF6

Number of citations of the paper that reports this interaction (PubMedID 16737952)
22

Data Source:
HPRD (in vitro, in vivo)

		ASAP3	ARF6
Description		ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	ADP ribosylation factor 6
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytosol Focal Adhesion Intracellular Membrane-bounded Organelle	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding Thioesterase Binding Protein N-terminus Binding
	Biological Process	Cell Migration Positive Regulation Of GTPase Activity Regulation Of Stress Fiber Assembly	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development
Pathways			TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling
Drugs			5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid
Diseases
GWAS		Cholesterol, total ( 24097068) Total cholesterol levels ( 28334899)	Erythema nodosum in inflammatory bowel disease ( 24487271)
Interacting Genes		7 interacting genes: ARF6 CRK MTNR1A PDZD3 REL TFCP2 UBE3A	42 interacting genes: AGAP1 ALDH5A1 AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 LSM7 MGAM MPP5 MT2A PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SPAG9 TOGARAM1 ZNF709
Entrez ID		55616	382
HPRD ID		11662	02714
Ensembl ID		ENSG00000088280	ENSG00000165527
Uniprot IDs		A0A024RAB1 B4DRP2 Q8TDY4	P62330
PDB IDs		2B0O 3LVQ 3LVR	1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ
Enriched GO Terms of Interacting Partners?
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