ARF6 and ALDH5A1

		ARF6	ALDH5A1
Description		ADP ribosylation factor 6	aldehyde dehydrogenase 5 family member A1
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GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Membrane Endocytic Vesicle Filopodium Membrane Early Endosome Membrane Cleavage Furrow Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Glutamatergic Synapse	Mitochondrion Mitochondrial Matrix
	Molecular Function	GTPase Activity Protein Binding GTP Binding Thioesterase Binding Protein N-terminus Binding	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Identical Protein Binding
	Biological Process	Liver Development Intracellular Protein Transport Cell Cycle Cell Adhesion Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Myeloid Cell Apoptotic Process Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	Glucose Metabolic Process Acetate Metabolic Process Succinate Metabolic Process Glutamate Metabolic Process Glutamine Metabolic Process Glycerophospholipid Metabolic Process Galactosylceramide Metabolic Process Glutathione Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Respiratory Electron Transport Chain Neurotransmitter Catabolic Process Short-chain Fatty Acid Metabolic Process
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	Degradation of GABA
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	Succinic acid NADH Valproic Acid Chlormerodrin
Diseases			Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Interacting Genes		42 interacting genes: AGAP1 ALDH5A1 AP1B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CYTH1 CYTH2 EXOC5 EZR HTR2A IKBKG ITSN1 LSM7 MGAM MPP5 MT2A PIP5K1A PIP5K1C PLD1 PRPF39 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 RPLP1 SMAP1 SMARCC2 SPAG9 TOGARAM1 ZNF709	3 interacting genes: ABAT ARF6 MAGEA11
Entrez ID		382	7915
HPRD ID		02714	08361
Ensembl ID		ENSG00000165527	ENSG00000112294
Uniprot IDs		P62330	P51649 X5D299 X5DQN2
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ	2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?
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