SHQ1 and DKC1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SHQ1	DKC1
Description		SHQ1, H/ACA ribonucleoprotein assembly factor	dyskerin pseudouridine synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body	Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cytoplasm Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex
	Molecular Function	Protein Binding Unfolded Protein Binding	Telomerase Activity RNA Binding Protein Binding Pseudouridine Synthase Activity Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Box H/ACA SnoRNP Assembly Ribonucleoprotein Complex Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Negative Regulation Of RRNA Processing	Enzyme-directed RRNA Pseudouridine Synthesis Box H/ACA SnoRNA 3'-end Processing RRNA Processing RNA Processing Telomere Maintenance Via Telomerase RRNA Pseudouridine Synthesis SnRNA Pseudouridine Synthesis Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Telomerase RNA Stabilization Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body MRNA Pseudouridine Synthesis
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases			Hoyeraal-Hreidarsson syndrome Dyskeratosis congenita (DC), including: X-linked dyskeratosis congenita (DKCX); Autosomal dominant dyskeratosis congenita (DKCA1); Autosomal recessive dyskeratosis congenita (DKCB1)
GWAS		Metabolite levels ( 23823483) Type 2 diabetes ( 30297969)
Interacting Genes		3 interacting genes: DKC1 GMCL1 GMCL2	11 interacting genes: CSNK2A1 DAXX EEF1G EIF3F ERG LYPLA2 MAPK6 RUVBL1 SHQ1 SSR1 TERC
Entrez ID		55164	1736
HPRD ID		07682	02129
Ensembl ID		ENSG00000144736	ENSG00000130826
Uniprot IDs		Q6PI26	O60832
PDB IDs		2MNW 4PBD 4PCK
Enriched GO Terms of Interacting Partners?
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