MED1 and THRA

Number of citations of the paper that reports this interaction (PubMedID 9653119)
125

Data Source:
HPRD (in vitro, in vivo)

		MED1	THRA
Description		mediator complex subunit 1	thyroid hormone receptor alpha
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Transcription Coactivator Activity Thyroid Hormone Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Mediator Complex Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Signaling Receptor Activity Transcription Regulatory Region DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Regulation Of Lipid Metabolic Process Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Regulation Of Cell Cycle Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition ERK1 And ERK2 Cascade Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Brain Development Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Response To Lipid Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression	Nuclear Receptor transcription pathway
Drugs		Becocalcidiol	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid Eprotirome NRP409
Diseases
GWAS		Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)	Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		44 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RBM5 RORA RPA2 RXRA SREBF1 THRA THRB TP53 VDR YWHAH YWHAQ	62 interacting genes: - AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MTNR1B NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		5469	7067
HPRD ID		05055	07185
Ensembl ID		ENSG00000125686	ENSG00000126351
Uniprot IDs		Q15648	P10827 Q6FH41
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6K5O	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
Enriched GO Terms of Interacting Partners?
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