THRA and BTG1

Number of citations of the paper that reports this interaction (PubMedID 15674337)
22

Data Source:
HPRD (in vitro, in vivo)

		THRA	BTG1
Description		thyroid hormone receptor alpha	BTG anti-proliferation factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Chromatin DNA Binding Signaling Receptor Activity Transcription Regulatory Region DNA Binding Protein-containing Complex Binding Thyroid Hormone Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Mediated Signaling Pathway Regulation Of Thyroid Hormone Mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Brain Development Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process Response To Lipid Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription, Initiation	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Nuclear Receptor transcription pathway	FOXO-mediated transcription of cell cycle genes
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid Eprotirome NRP409
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)	Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		62 interacting genes: - AKAP13 AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MTNR1B NCOA1 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3	13 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 HOXB9 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		7067	694
HPRD ID		07185	15912
Ensembl ID		ENSG00000126351	ENSG00000133639
Uniprot IDs		P10827 Q6FH41	P62324 Q6IBC8
PDB IDs		1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
Enriched GO Terms of Interacting Partners?
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