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MED1 and YWHAH
Number of citations of the paper that reports this interaction (PubMedID
11266503
)
23
Data Source:
HPRD
(in vitro)
MED1
YWHAH
Description
mediator complex subunit 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Membrane
Mediator Complex
Protein-DNA Complex
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Intercalated Disc
Extracellular Exosome
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Estrogen Receptor Binding
Nuclear Receptor Transcription Coactivator Activity
Thyroid Hormone Receptor Coactivator Activity
Chromatin DNA Binding
Nuclear Hormone Receptor Binding
Mediator Complex Binding
Vitamin D Receptor Binding
Retinoic Acid Receptor Binding
Peroxisome Proliferator Activated Receptor Binding
Thyroid Hormone Receptor Binding
LBD Domain Binding
Ubiquitin Protein Ligase Activity
Promoter-specific Chromatin Binding
Actin Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Sodium Channel Regulator Activity
Enzyme Binding
Protein Domain Specific Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Ion Channel Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Angiogenesis
Liver Development
Embryonic Placenta Development
Lens Development In Camera-type Eye
Thyroid Hormone Mediated Signaling Pathway
Ventricular Trabecula Myocardium Morphogenesis
Retinal Pigment Epithelium Development
Regulation Of Transcription By RNA Polymerase I
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Thyroid Hormone Generation
Protein Import Into Nucleus
Androgen Biosynthetic Process
Brain Development
Lactation
Positive Regulation Of Gene Expression
Negative Regulation Of Keratinocyte Proliferation
Protein Ubiquitination
Regulation Of Lipid Metabolic Process
Keratinocyte Differentiation
Monocyte Differentiation
Intracellular Steroid Hormone Receptor Signaling Pathway
Animal Organ Regeneration
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Embryonic Heart Tube Development
Embryonic Hindlimb Morphogenesis
Embryonic Hemopoiesis
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Megakaryocyte Development
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Enucleate Erythrocyte Development
Regulation Of Cell Cycle
Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Mammary Gland Branching Involved In Thelarche
Mammary Gland Branching Involved In Pregnancy
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of G0 To G1 Transition
ERK1 And ERK2 Cascade
Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Signaling Receptor Activity
Positive Regulation Of Hepatocyte Proliferation
Regulation Of RNA Biosynthetic Process
Regulation Of Sodium Ion Transport
Glucocorticoid Catabolic Process
Intracellular Protein Transport
Substantia Nigra Development
Glucocorticoid Receptor Signaling Pathway
Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Membrane Organization
Membrane Depolarization During Action Potential
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Estrogen-dependent gene expression
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
Becocalcidiol
Phenethyl Isothiocyanate
Diseases
GWAS
Asthma (
31619474
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (
29403010
)
Lung function (FVC) (
30061609
)
Rheumatoid arthritis (
30423114
24390342
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systemic lupus erythematosus (
24871463
)
Ulcerative colitis (
20228799
)
Post bronchodilator FEV1 (
26634245
)
Type 2 diabetes (
30297969
)
Interacting Genes
44 interacting genes:
AKAP9
AR
BRCA1
CASK
CTDP1
ESR1
ESR2
EZH2
GABPA
GATA1
GATA3
GATA4
GATA6
GJB5
HNF4A
KIF1A
MDM2
MED12
MED14
MED25
MED8
MED9
MYC
NCOA6
NR1H2
NR1I3
NR3C1
NR4A1
PIN1
PPARA
PPARG
PPARGC1A
RARA
RBM5
RORA
RPA2
RXRA
SREBF1
THRA
THRB
TP53
VDR
YWHAH
YWHAQ
63 interacting genes:
ABL1
ARHGEF28
BAD
BCR
BRAF
CDC25B
CDC25C
CDK16
CDKN1B
CHRNA4
CREBBP
EPB41L2
EPB41L3
ESR1
ESR2
EXO1
GREM1
HSPB1
ING1
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KIF5B
KLC3
KRT18
MAP3K3
MAP3K5
MARK4
MDM4
MED1
MST1R
NCOA1
NCOA2
NCOA3
NEK1
NR3C1
NRIP1
PARD3
PARD6A
PARD6B
PDPK1
PRKCI
PRKN
PTH1R
RAF1
REM1
RIMS1
RIMS2
RPH3A
SAMSN1
SNCA
SRC
THRA
TLX2
TNFAIP3
TPH1
TSC1
TSC2
YWHAE
YWHAG
ZFP36
Entrez ID
5469
7533
HPRD ID
05055
00215
Ensembl ID
ENSG00000125686
ENSG00000128245
Uniprot IDs
Q15648
A0A024R1K7
Q04917
Q9H4N8
PDB IDs
1RJK
1RK3
1RKG
1RKH
2O4J
2O4R
2ZFX
3A2H
3AUN
3VJS
3VJT
3VRT
3VRU
3VRV
3VRW
3W0G
3W0H
3W0I
3W0J
3W5P
3W5Q
3W5R
3W5T
3WT5
3WT6
3WT7
3WTQ
4YNK
5AWJ
5AWK
5B41
5B5B
5GIC
5GID
5GIE
5XPM
5XPN
5XPO
5XPP
5XUQ
5XZF
5XZH
5ZWE
5ZWF
5ZWH
5ZWI
6D94
6K5O
2C63
2C74
Enriched GO Terms of Interacting Partners
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