TOLLIP and N4BP2

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		TOLLIP	N4BP2
Description		toll interacting protein	NEDD4 binding protein 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Nuclear Body Azurophil Granule Lumen Specific Granule Lumen Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytosol
	Molecular Function	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding	Endonuclease Activity Protein Binding ATP Binding ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Neutrophil Degranulation Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway	Phosphorylation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Idiopathic pulmonary fibrosis ( 24429156)	Platelet thrombus formation ( 22550155)
Interacting Genes		44 interacting genes: ACTN2 ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 GGA1 GGA2 GGA3 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 NTAQ1 ODAM PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WBP2 WRNIP1 XRN2 ZBTB16 ZHX1	5 interacting genes: BCL3 CREBBP EP300 NEDD4 TOLLIP
Entrez ID		54472	55728
HPRD ID		05887	11382
Ensembl ID		ENSG00000078902	ENSG00000078177
Uniprot IDs		B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2	B2ZZ87 Q86UW6
PDB IDs		1WGL 2N31	2D9I 2VKC 3BHB 3FAU
Enriched GO Terms of Interacting Partners?
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