LEPR and RNF41

Number of citations of the paper that reports this interaction (PubMedID 21378310)
22

Data Source:
BioGRID (protein complementation assay)

		LEPR	RNF41
Description		leptin receptor	ring finger protein 41
Image
GO Annotations	Cellular Component	Extracellular Region External Side Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Ral GTPase Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Glycogen Metabolic Process Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Negative Regulation Of Autophagy Glial Cell Proliferation Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Cellular Response To Leptin Stimulus Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling Regulation Of Transport Negative Regulation Of Hydrolase Activity Regulation Of Feeding Behavior Energy Homeostasis Bone Growth Positive Regulation Of Cold-induced Thermogenesis	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Proliferation Proteasomal Protein Catabolic Process Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Leptin Metreleptin
Diseases
GWAS		Age at voice drop ( 27182965) Blood protein levels ( 30072576 29875488 28240269) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) C-reactive protein ( 19567438 18439548 23844046 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) Hip circumference ( 28552196) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Asthma ( 31619474)
Interacting Genes		16 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	39 interacting genes: ADRB2 AP2S1 APP ARL6IP4 ASB6 BIRC6 C1orf109 ERBB3 ERBB4 GDF11 IRS4 ISCA2 KDM3B LEPR LZTS2 MAGEL2 MARK2 MNAT1 MTNR1A MTNR1B NEUROD4 ORMDL2 PPP1R1A RFC4 RNF166 RRM2B SUOX TBATA TRIM32 TRIM8 TSG101 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		3953	10193
HPRD ID		03001	11520
Ensembl ID		ENSG00000116678	ENSG00000181852
Uniprot IDs		P48357 Q4G138	A0A024RB33 Q9H4P4
PDB IDs		3V6O 6E2P	2FZP 2GWF
Enriched GO Terms of Interacting Partners?
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