C1QA and UBQLN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		C1QA	UBQLN2
Description		complement C1q A chain	ubiquilin 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Postsynapse	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Amyloid-beta Binding Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Cargo recognition for clathrin-mediated endocytosis
Drugs		Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Interacting Genes		28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SLC25A47 UBQLN1 UBQLN2	22 interacting genes: ADRM1 ATXN7 BTRC C1QA CD93 FBXO25 FUS HERC3 HERPUD1 HNRNPA3 HSPA13 MTNR1B PRPF40A PSMA2 PSMA5 PSMD4 RNF11 RPN1 SMURF1 UBC UBE3A UBQLN4
Entrez ID		712	29978
HPRD ID		00393	02224
Ensembl ID		ENSG00000173372	ENSG00000188021
Uniprot IDs		A0A024RAG6 P02745	Q9UHD9
PDB IDs		1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ	1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
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