POLE and GINS4

Number of citations of the paper that reports this interaction (PubMedID 21705323)
37

Data Source:
BioGRID (pull down)

		POLE	GINS4
Description		DNA polymerase epsilon, catalytic subunit	GINS complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Epsilon DNA Polymerase Complex	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Single-stranded DNA 3'-5' Exodeoxyribonuclease Activity 4 Iron, 4 Sulfur Cluster Binding	Protein Binding 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication Initiation Leading Strand Elongation Base-excision Repair, Gap-filling Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication DNA Replication Proofreading Embryonic Organ Development Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Unwinding of DNA Unwinding of DNA
Drugs		Cladribine
Diseases
GWAS		Body mass index ( 26426971) Metabolite levels ( 23823483) Urate levels in overweight individuals ( 25811787)
Interacting Genes		12 interacting genes: GINS4 MDM2 PCNA POLA1 POLD4 POLE2 POLE4 RAD17 SCARB1 STK19 TOPBP1 XRCC5	9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1
Entrez ID		5426	84296
HPRD ID		07177	11583
Ensembl ID		ENSG00000177084	ENSG00000147536
Uniprot IDs		Q07864	Q9BRT9
PDB IDs		5VBN	2E9X 2EHO 2Q9Q
Enriched GO Terms of Interacting Partners?
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