GINS4 and CDC45

Number of citations of the paper that reports this interaction (PubMedID 22374673)
7

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GINS4	CDC45
Description		GINS complex subunit 4	cell division cycle 45
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex	Nucleus Nucleoplasm Nuclear Pre-replicative Complex Cytoplasm Centrosome DNA Replication Preinitiation Complex Replication Fork Protection Complex
	Molecular Function	Protein Binding 3'-5' DNA Helicase Activity	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Unwinding of DNA Unwinding of DNA	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1	23 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 TOPBP1 TRAPPC3 UBC
Entrez ID		84296	8318
HPRD ID		11583	09145
Ensembl ID		ENSG00000147536	ENSG00000093009
Uniprot IDs		Q9BRT9	O75419
PDB IDs		2E9X 2EHO 2Q9Q	5DGO
Enriched GO Terms of Interacting Partners?
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