GINS4 and POLA1

Number of citations of the paper that reports this interaction (PubMedID 21705323)
37

Data Source:
BioGRID (pull down)

		GINS4	POLA1
Description		GINS complex subunit 4	DNA polymerase alpha 1, catalytic subunit
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm Replication Fork Protection Complex	Chromatin Nucleus Nuclear Envelope Nucleoplasm Alpha DNA Polymerase:primase Complex Nucleolus Cytosol Nuclear Matrix
	Molecular Function	Protein Binding 3'-5' DNA Helicase Activity	Nucleotide Binding Nucleoside Binding DNA Binding Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Purine Nucleotide Binding Pyrimidine Nucleotide Binding Protein Kinase Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication DNA Duplex Unwinding	G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Synthesis Involved In DNA Repair DNA Replication DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Leading Strand Elongation Lagging Strand Elongation DNA Repair Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Telomere Maintenance Via Semi-conservative Replication Mitotic DNA Replication Initiation DNA Synthesis Involved In UV-damage Excision Repair
Pathways		Unwinding of DNA Unwinding of DNA	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand G1/S-Specific Transcription
Drugs			Cladribine Clofarabine Fludarabine Nelarabine
Diseases
GWAS
Interacting Genes		9 interacting genes: CDC45 GINS1 GINS2 GINS3 MCM2 POLA1 POLD1 POLE SIK1	24 interacting genes: CCNA2 CCNB1 CDC45 CDK1 CDK2 CDK2AP1 GINS4 GLRA2 HELB IL1RAPL1 KLHL15 PARP1 POLA2 POLD1 POLE PRIM2 RAD51 RB1 RBMS1 S100G SERPINA3 SMC1A TP53 XRCC5
Entrez ID		84296	5422
HPRD ID		11583	02416
Ensembl ID		ENSG00000147536	ENSG00000101868
Uniprot IDs		Q9BRT9	A6NMQ1 P09884
PDB IDs		2E9X 2EHO 2Q9Q	1K0P 1K18 1N5G 4Q5V 4QCL 4Y97 5EXR 5IUD 6AS7
Enriched GO Terms of Interacting Partners?
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