MTA2 and TSC22D3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MTA2	TSC22D3
Description		metastasis associated 1 family member 2	TSC22 domain family member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Membrane NuRD Complex Protein-containing Complex	Nucleus Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Ion Transmembrane Transport Negative Regulation Of Activation-induced Cell Death Of T Cells
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Stimuli-sensing channels
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: APPL1 APPL2 BCL11B ESR1 FKBP3 H3-4 HDAC2 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C YY1	13 interacting genes: C19orf57 DCLK2 FOS HPCAL4 JUN MAD1L1 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 RELA SUMO1
Entrez ID		9219	1831
HPRD ID		07233	04266
Ensembl ID		ENSG00000149480	ENSG00000157514
Uniprot IDs		A0A024R534 O94776	Q5JRJ2 Q99576
PDB IDs
Enriched GO Terms of Interacting Partners?
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