PLN and PPP1R3A

Number of citations of the paper that reports this interaction (PubMedID 9845327)
8

Data Source:
HPRD (in vitro, in vivo)

		PLN	PPP1R3A
Description		phospholamban	protein phosphatase 1 regulatory subunit 3A
Image
GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Integral Component Of Membrane
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Glycogen Metabolic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794) Resting heart rate ( 27798624)	Blood pressure (smoking interaction) ( 25189868) Chronotype ( 30696823) Hand grip strength ( 29691431) Schizophrenia ( 28991256 30285260)
Interacting Genes		14 interacting genes: ATP2A1 ATP2A2 BCL2L13 CREB3 CREB3L1 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79	2 interacting genes: PLN RPS6KA1
Entrez ID		5350	5506
HPRD ID		01395	02950
Ensembl ID		ENSG00000198523	ENSG00000154415
Uniprot IDs		P26678 Q5R352	Q16821
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN	5ZQV
Enriched GO Terms of Interacting Partners?
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