PLN and EDA

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		PLN	EDA
Description		phospholamban	ectodysplasin A
Image
GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Membrane Mitochondrial Membrane Vesicle Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex	Extracellular Region Collagen Trimer Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity ATPase Binding	Signaling Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Calcium Ion Transport Notch Signaling Pathway Blood Circulation Regulation Of Heart Contraction Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of ATPase Activity Response To Insulin Response To Testosterone Negative Regulation Of Catalytic Activity Cardiac Muscle Tissue Development Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Negative Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Binding Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Calcium-transporting ATPase Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Ion homeostasis Ion transport by P-type ATPases	TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 23166209 24952745 19305408 19305409 19587794) Resting heart rate ( 27798624)	Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		14 interacting genes: ATP2A1 ATP2A2 BCL2L13 CREB3 CREB3L1 DMPK DVL3 EDA LDLRAD1 PPP1R3A PRKACA S100A1 SLN TMEM79	15 interacting genes: ATP6V0C CYB561 DOLK EDA2R EDAR EMP3 FURIN GIMAP5 LEPROTL1 MAL NIPAL3 OSTC OSTCP1 PLN SEC22A
Entrez ID		5350	1896
HPRD ID		01395	02347
Ensembl ID		ENSG00000198523	ENSG00000158813
Uniprot IDs		P26678 Q5R352	A0A0U5J797 Q92838
PDB IDs		1K9N 1KCH 1PLN 1PLP 1PSL 1ZLL 2HYN	1RJ7 1RJ8
Enriched GO Terms of Interacting Partners?
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