UBASH3A and SF3B4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		UBASH3A	SF3B4
Description		ubiquitin associated and SH3 domain containing A	splicing factor 3b subunit 4
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Regulation Of Cytokine Production Negative Regulation Of T Cell Receptor Signaling Pathway	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Diverticular disease ( 30177863) Medication use (thyroid preparations) ( 31015401) Primary sclerosing cholangitis ( 27992413) Rheumatoid arthritis ( 30423114 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 21829393 25751624 19430480 18840781) Vitiligo ( 20410501 27723757)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth length ( 25281659) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 20881960 31562340 18391951) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		17 interacting genes: CBL CBS DAZAP2 IKBKG KCNE1 KRT40 MAP3K7 PRKN REL RNF41 SF3B4 SPRY2 TP53BP2 TRIM37 UBB UBC UBE2L3	42 interacting genes: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 NCK2 NUB1 PPP1R16B PRPF40A RBM10 RBM39 RBM4 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 UBASH3A WBP4 WDR77 ZCCHC10
Entrez ID		53347	10262
HPRD ID		06904	12028
Ensembl ID		ENSG00000160185	ENSG00000143368
Uniprot IDs		P57075	B3KUJ0 Q15427
PDB IDs		2CRN 5WDI	1X5T 5GVQ 5Z56 5Z57 5Z58 6AH0 6QX9
Enriched GO Terms of Interacting Partners?
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