SF3B4 and FRK

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		SF3B4	FRK
Description		splicing factor 3b subunit 4	fyn related Src family tyrosine kinase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Ribonucleoprotein Complex	Extracellular Region Intracellular Nucleus Nucleoplasm Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Splicing Factor Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Neutrophil Degranulation
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Neutrophil degranulation Regulation of PTEN stability and activity
Drugs			Dasatinib Regorafenib
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth length ( 25281659) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 20881960 31562340 18391951) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Age-related macular degeneration ( 21665990) Appendicular lean mass ( 28724990) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Choroid plexus volume ( 31530798) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diastolic blood pressure ( 27841878) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) HDL cholesterol levels ( 30698716) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longevity ( 30294719) Photic sneeze reflex ( 27182965) Total cholesterol levels ( 28334899) Urate levels ( 23263486)
Interacting Genes		42 interacting genes: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 NCK2 NUB1 PPP1R16B PRPF40A RBM10 RBM39 RBM4 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 UBASH3A WBP4 WDR77 ZCCHC10	6 interacting genes: BNIP2 EGFR KHDRBS1 RB1 SF3B4 SKAP2
Entrez ID		10262	2444
HPRD ID		12028	05954
Ensembl ID		ENSG00000143368	ENSG00000111816
Uniprot IDs		B3KUJ0 Q15427	P42685
PDB IDs		1X5T 5GVQ 5Z56 5Z57 5Z58 6AH0 6QX9
Enriched GO Terms of Interacting Partners?
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