PLA2G4A and MAPKAPK5

Number of citations of the paper that reports this interaction (PubMedID 10978317)
53

Data Source:
HPRD (in vitro, in vivo)

		PLA2G4A	MAPKAPK5
Description		phospholipase A2 group IVA	MAPK activated protein kinase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Arachidonic Acid Metabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Proliferation Icosanoid Biosynthetic Process Glycerophospholipid Catabolic Process Arachidonic Acid Secretion Cellular Response To Antibiotic	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping
Pathways		phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs		Fluticasone propionate Quinacrine Niflumic Acid
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)	Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Psoriasis ( 28537254)
Interacting Genes		24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B	29 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		5321	8550
HPRD ID		08986	09467
Ensembl ID		ENSG00000116711	ENSG00000089022
Uniprot IDs		B4DZI4 P47712	Q8IW41
PDB IDs		1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?