MAPKAPK5 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 9628874)
84

Data Source:
BioGRID (enzymatic study)

		MAPKAPK5	HSPB2
Description		MAPK activated protein kinase 5	heat shock protein family B (small) member 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding	Protein Binding Enzyme Activator Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping	Response To Unfolded Protein Positive Regulation Of Catalytic Activity
Pathways		Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Psoriasis ( 28537254)
Interacting Genes		29 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576	89 interacting genes: A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BEX4 BGN C1QA CAPZA2 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DDX10 DMPK DUSP1 EEF1A1 EIF4A2 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HSPB3 HSPB8 LGALS1 MAPKAPK5 MB MCCC2 MDH1 MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PGM1 PKP2 PPM1K RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 TATDN1 TCAP THEMIS2 THUMPD2 TNNI3 TTN TXNIP UBL5 WDR1 ZNF335
Entrez ID		8550	3316
HPRD ID		09467	03712
Ensembl ID		ENSG00000089022	ENSG00000170276
Uniprot IDs		Q8IW41	A8KAH6 Q16082
PDB IDs			6F2R
Enriched GO Terms of Interacting Partners?
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